글로버메뉴 바로가기 본문 바로가기 하단메뉴 바로가기

논문검색은 역시 페이퍼서치

> 대한결핵 및 호흡기학회 > 대한결핵및호흡기학회 추계학술발표초록집 > 126권 0호

Combined effects of Sulforaphane(SF) and Curcumin(CU) against particulate matter(PM)-induced oxidative stress and inflammation in human bronchial epithelial cells

Combined effects of Sulforaphane(SF) and Curcumin(CU) against particulate matter(PM)-induced oxidative stress and inflammation in human bronchial epithelial cells

손은숙 , 이영은 , 경선영 , 김세희 , 박정웅 , 김유진 , 정성환

- 발행기관 : 대한결핵 및 호흡기학회

- 발행년도 : 2018

- 간행물 : 대한결핵및호흡기학회 추계학술발표초록집, 126권 0호

- 페이지 : pp.261-261 ( 총 1 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

1,000
논문제목
초록(외국어)
Ambient airborne particulate matter(PM), an important component of environmental pollution, had been associated with multiple respiratory disease. Sulforaphane(SF) and Curcumin(CU) has a known as an antioxidant and anti-inflammatory agent in traditional medicine. We hypothesized that the combined SF/CU has protected against PM-induced lung damage by strong inhibition of oxidative stress and inflammation than single compound treatment. The results showed that PM10 exposure of epithelial cells increased ROS generation and pro-inflammatory cytokines. While, the treatment of SF, CU or combined SF/CU significantly increased the expression of Nrf2-downstream genes such as HO-1, NQO1-1, CAT and TXNRD1 by triggering the activate of Nrf2 transcription in the nucleus and decreased intracellular ROS generation. In addition, these compound strikingly inhibited the production of pro-inflammatory cytokines by downregulation the PM-induced inflammatory mediators, such as IL-6, IL-8, CXCL1 and MCP-1. The combined SF/CU showed the highest effectiveness in PM-induced epithelial injury. We confirmed these compound decreased the NF-κB signaling activation in PM-exposed epithelial cells. These results suggest that the combined SF/CU inhibited PM-induced oxidative stress and inflammation by increasing of antioxidant genes through Nrf2 transcriptional activity and by decreasing of pro-inflammatory cytokines through the mediation of NF-κB signaling. Our findings may provide experimental evidence and explanation for aggravated respiratory diseases by PM.

논문정보
  • - 주제 : 의약학분야 > 내과학
  • - 발행기관 : 대한결핵 및 호흡기학회
  • - 간행물 : 대한결핵및호흡기학회 추계학술발표초록집, 126권 0호
  • - 발행년도 : 2018
  • - 페이지 : pp.261-261 ( 총 1 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2019-500-001722754
저널정보
  • - 주제 : 의약학분야 > 내과학
  • - 성격 : 학술발표
  • - 간기 : 연간
  • - 국내 등재 : -
  • - 해외 등재 : -
  • - ISSN :
  • - 수록범위 : 1960–2020
  • - 수록 논문수 : 7073