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> 한국생약학회 > Natural Product Sciences > 23권 3호

Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds

Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds

( Wahyu Widowati ) , ( Andani Puspita Rani ) , ( R. Amir Hamzah ) , ( Seila Arumwardana ) , ( Ervi Afifah ) , ( Hanna Sari W. Kusuma ) , ( Dwi Davidson Rihibiha ) , ( Hayatun Nufus ) , ( Annisa Amalia )

- 발행기관 : 한국생약학회

- 발행년도 : 2017

- 간행물 : Natural Product Sciences, 23권 3호

- 페이지 : pp.192-200 ( 총 9 페이지 )


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논문제목
초록(외국어)
Skin aging is a complex biological process due to intrinsic and extrinsic factors. Free radical oxidative is one of extrinsic factors that induce activation of collagenase, elastase and hyaluronidase. Natural product from plants has been used as antioxidant and antiaging. This study aimed to evaluate antioxidant and antiaging properties of Hibiscus sabdariffa extract (HSE) and its compounds including myricetin, ascorbic acid, and β carotene. The phytochemical of H. sabdariffa was determined using modified Farnsworth method and presence of phenols, flavonoids and tannins were in moderate content, whereas triterpenoids and alkaloids were in low content. Total phenolic content performed using Folin-Ciocalteu method, was 23.85 μg GAE/mg. Quantitative analysis of myricetin, β-carotene, and ascorbic acid of HSE was performed with Ultra-High Performance Liquid Chromatography (UHPLC) that shows 78.23 μg/mg myricetin, 0.034 μg/mg β-carotene, whilst ascorbic acid was not detected. HSE has lower activity on DPPH (IC50 = 195.73 μg/mL) compared to β-carotene, the lowest in ABTS assay (IC50 = 74.58 μg/mL) and low activity in FRAP assay (46.24 μM Fe(II)/μg) compared to myricetin, β-carotene. Antiaging was measured through inhibitory activity of collagenase, elastase, and hyaluronidase. HSE had weakest collagenase inhibitory activity (IC50= 750.33 μg/mL), elastase inhibitory activity (103.83 μg/mL), hyaluronidase inhibitory activity (IC50 = 619.43 μg/mL) compared to myricetin, β-carotene, and ascorbic acid. HSE contain higher myricetin compared to β-carotene. HSE has moderate antioxidants and lowest antiaging activities. Myricetin is the most active both antioxidant and antiaging activities.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 23권 3호
  • - 발행년도 : 2017
  • - 페이지 : pp.192-200 ( 총 9 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2018-500-000686726
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2021
  • - 수록 논문수 : 1165