글로버메뉴 바로가기 본문 바로가기 하단메뉴 바로가기

논문검색은 역시 페이퍼서치

> 한국치위생과학회 > 치위생과학회지 > 11권 5호

자일리톨 처리 농도에 따른 자일리톨 감성균주와 내성균주의 독력 비교

Comparison of Virulence in Xylitol-Sensitive and -Resistant Streptococcus mutans to Different Concentrations of Xylitol

임상욱 ( Sang Uk Im ) , 안상헌 ( Sang Hun Ahn ) , 송근배 ( Keun Bae Song )

- 발행기관 : 한국치위생과학회

- 발행년도 : 2011

- 간행물 : 치위생과학회지, 11권 5호

- 페이지 : pp.411-416 ( 총 6 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

4,500
논문제목
초록(외국어)
Streptococcus mutans (S. mutans) is the major causative bacteria in dental caries. Xylitol is effective anticarious natural sugar substitute by inhibiting the virulence of S. mutans. However, long-term xylitol consumption leads to the emergence of the xylitol-resistant (XR) strains which means xylitol is no more inhibited their growth. We therefore confirmed the general characteristics and the virulence factors of the xylitol-sensitive (XS) and XR S. mutans for different concentrations of xylitol. S. mutans KCTC 3065 was maintained in TYE medium containing 0.4% glucose with 1% xylitol during 30 days at 37oC, 10% CO2 to form XR strain. The strains were transferred to new medium every 24 hr and the same procedures without xylitol were repeated for the formation of XS S. mutans. Both XS and XR were cultured in different concentrations of xylitol (0%, 0.1% and 1%) then, cell growth, acid production and mRNA expression of gtf genes were analyzed. Xylitol reduced the cell growth of XS S. mutans in dose-dependent manner, but not reduced that of XR. Xylitol inhibited acid production of XS in dose-dependent manner, but not inhibited that of XR. Xylitol reduced the gtfB and gtfD mRNA expression of XS S. mutans which genes synthesized soluble and insoluble extracellular polysaccharides, but not reduced that of XR. These results indicate that the virulence of XR S. mutans is different characters of XS strains, which suggests XR strains may have different cariogenicity of XS strains. Further study is needed to explain the mechanism related to extracellular polysaccharide in the XR strains.

논문정보
  • - 주제 : 의약학분야 > 기초치의학
  • - 발행기관 : 한국치위생과학회
  • - 간행물 : 치위생과학회지, 11권 5호
  • - 발행년도 : 2011
  • - 페이지 : pp.411-416 ( 총 6 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-510-002606013
저널정보
  • - 주제 : 의약학분야 > 기초치의학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 1598-4478
  • - 수록범위 : 2001–2021
  • - 수록 논문수 : 1038