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> 대한예방치과·구강보건학회 > 대한구강보건학회지 > 35권 1호

원저 : 다양한 탄수화물 배양 조건에 따른 xylitol-resistant Streptococcus mutans와 xylitol-resistant Streptococcus sobrinus의 독력 비교

Original Article : Comparison of virulence in xylitol-resistant mutans streptococci exposed to various carbohydrates

정선영 ( Sun Young Chung ) , 김지혜 ( Ji Hye Kim ) , 최연희 ( Youn Hee Choi ) , 송근배 ( Keun Bae Song )

- 발행기관 : 대한예방치과·구강보건학회

- 발행년도 : 2011

- 간행물 : 대한구강보건학회지, 35권 1호

- 페이지 : pp.1-9 ( 총 9 페이지 )


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논문제목
초록(외국어)
Objective. This study aimed to compare the cariogenic traits in xylitol-resistant (XR) mutans streptococci (MS) exposed to various carbohydrates. Methods. To select the XR MS, S. mutans KCTC 3065 and S. sobrinus KCTC 3308 were cultured in TYE medium containing 0.5% glucose and 1% (66 mM) xylitol at 37℃, 10% CO2 conditions for 30 days. Both the strains were divided into the following 4 groups in terms of the culture medium that was used: (1) 0.5% glucose containing basal culture medium (BCM), (2) BCM plus 0.5% sucrose (BCM-S), (3) BCM plus 0.5% fructose (BCM-F), and (4) BCM plus 0.5% maltose (BCM-M). To examine the cariogenic traits, cell growth, acid production, mRNA expressions related to glucan synthesis, and the formation of extracellular polysaccharides (ECPs) in each culture media, they were measured by ELISA, pH meter, real-time RT-PCR, and TEM, respectively in the 4 culture media. Results. The characteristics of xylitol-resistant MS were identified by confirming that the growth curve on glucose in the presence of xylitol was identical to that in its absence. Both the S. mutans and S. sobrinus expressed the final pH without any significant differences depending on carbohydrate sources. Cell growth, gene expression levels and the formation of ECPs were apparently distinct in S. mutans depending on sugar sources whereas these were not different in S. sobrinus except for BCM-S. Conclusions. The virulence of XR S. mutans responded differently when grown in various carbohydrates, yet the virulence of XR S. sobrinus, in general, showed no difference depending on sugar sources except for BCM-S. Further study is needed to explain the metabolite mechanism related to carbohydrate sources inside the XR MS cells.

논문정보
  • - 주제 : 의약학분야 > 기초치의학
  • - 발행기관 : 대한예방치과·구강보건학회
  • - 간행물 : 대한구강보건학회지, 35권 1호
  • - 발행년도 : 2011
  • - 페이지 : pp.1-9 ( 총 9 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2012-510-001637541
저널정보
  • - 주제 : 의약학분야 > 기초치의학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 1225-388x
  • - 수록범위 : 1967–2021
  • - 수록 논문수 : 1675