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> 한국생약학회 > 생약학회지 > 46권 4호

원보 : LC-MS/MS를 이용한 향사육군자탕의 주요성분의 함량분석

Quantitative Analysis of Hyangsayukgunja-Tang Using an Ultra-Performance Liquid Chromatography Coupled to Electrospray Ionization Tandem Mass Spectrometry

서창섭 ( Chang Seob Seo ) , 신현규 ( Hyeun Kyoo Shin )

- 발행기관 : 한국생약학회

- 발행년도 : 2015

- 간행물 : 생약학회지, 46권 4호

- 페이지 : pp.352-364 ( 총 13 페이지 )


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5,300
논문제목
초록(외국어)
The aim of this study was to quantitatively analyze for quality assessment of eighteen marker compounds, including homogentisic acid, 3,4-dihydroxybenzaldehyde, spinosin, liquiritin, hesperidin, ginsenoside Rg1, liquiritigenin, ginsenoside Rb1, glycyrrhizin, 6-gingerol, atractylenolide III, honokiol, costunolide, dehydrocostuslactone, atractylenolide II, nootkatone, magnolol, and atractylenolide I, in Hyangsayukgunja-tang using an ultra-performance liquid chromatography-electrospray ionization- mass spectrometer. The column for separation of eighteen marker components were used a UPLC BEH C18 analytical column (2.1×100 mm, 1.7 μm) and kept at 45 o C by gradient elution with 0.1% (v/v) formic acid in water and acetonitrile as mobile phase. The flow rate and injection volume were 0.3 mL/min and 2.0 μL, respectively. The correlation coefficient of all marker compounds was ≥0.9914, which means good linearity, within the test ranges. The limits of detection and quantification values of the all analytes were in the ranges 0.04-1.11 and 0.13-3.33 ng/mL, respectively. As a result, five compounds, homogentisic acid, 3,4-dihydroxybenzaldehyde, spinosin, liquiritigenin, and atractylenolide I, in this sample were not detected and the amounts of the 13 compounds except for the 5 compounds were 8.10-6736.37 μg/g in Hyangsayukgunja-tang extract

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : 생약학회지, 46권 4호
  • - 발행년도 : 2015
  • - 페이지 : pp.352-364 ( 총 13 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2016-510-000601601
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 0253-3073
  • - 수록범위 : 1970–2021
  • - 수록 논문수 : 3326