This study measured basic physiological activities in keratinocyte and dermal fibroblasts of human HaCaT cells through the cell viability test of sandalwood essential oil. The results confirmed the safety of sandalwood essential oil. Clinical research on the effects on facial skin conditions was conducted with university students in their early twenties who thought that they had redness or sensitive or problem skin. The subjects were classified into the control group without any treatment, the oil group treated by manual lymph drainage(MLD) using jojoba oil, and the aroma group with treated by manual lymph drainage using the combination of jojoba oil and sandalwood essential oil. The results suggested that while the control group decreased in both moisture and sebum levels, the oil group and the aroma group showed a significant difference in a moisture level at p<.05 and p<.001 respectively and maintained a normal sebum level. It indicated an excellent effect on skin. This study suggested a more effective method in the skin care program for problem skin by treating MLD using sandalwood essential oil.