The study was designed to investigate the effects of visual, auditory, and visuoauditory cues on simple Serial Task Performance in heaithy adults. Methods: Sixty-three right-handed heaithy adults without history of neurological dysfunction were participated. A modified version of the Serial Reaction Time Task (SRTT) using five blocks of perceptual motor sequences was administered. The blocked paradigm consisted of the five blocks with randomly repeated 8 digit sequences with 5 repetition. Three types of sensory cue were employed: visual cue, auditory cue and visuoauditory cue. All subjects were assigned to press the matched botton as quickly and accurately as possible, when one of 8 stimulations was presented(one, two, three, four, five, six, seven, eight). The reaction time, accuracy, and P300 latency were measured during serial task performance. The mean reaction time(㎳), accuracy(%), and P300 latency(㎳) were compared between three types of cue using ANOVA. Results：The reaction time to auditory cue was significantly longer than visual and visuoauditory cue s(p<. 001). And accuracy to auditory cue was significantly lower than visual and visuoauditory cues (p<.001). All P300 latency (at Fz, Cz, Pz) were significantly longer than to visual and visuoauditory cues (p<.05). Conclusion：It is suggested that type of cues influence in choice reaction. These data may helpful in designing not only effective motor learning training programs for healthy persons but also reeducation programs for patients with neurological dysfunction.