Background: It is well known that atopic dermatitis(AD) is associated with other allergic diseases. Lately, links to diseases other than allergic disease have also been actively studied. Among them, the results of studies about AD comorbidities especially cardiovascular disease (CVD), vary from country to country. Objectives: To analyze whether the risk of CVD is different between AD patients and healthy controls using National Health Insurance Data in Korea. Methods: We got data from 2005 to 2016 from the Korean National Health Insurance Research Database. AD patients were selected as patients with one atopic dermatitis code and two AD-related tests. The control group matched the age and sex of AD patients. AD groups and Non-AD groups were selected as ratios of 1:5. And then, each group was investigated for accompanying metabolic syndrome and cardiovascular disease. Results: The incidence of metabolic diseases and CVD were significantly different between AD group and control group. Not only metabolic disease, but also CVD risk of AD patients was significantly higher than that of control group. Patients with AD had significantly higher risk of hyperlipidemia, hypertension and type 2 diabetes. AD patients also had higher risk of stroke myocardial infarction, angina and peripheral vascular disease. Except for hyperlipidemia, there was no difference in risk according to AD severity. Conclusion: Patients with AD have a greater risk of CVD than those without AD.