Ambient airborne particulate matter(PM), an important component of environmental pollution, had been associated with multiple respiratory disease. Sulforaphane(SF) and Curcumin(CU) has a known as an antioxidant and anti-inflammatory agent in traditional medicine. We hypothesized that the combined SF/CU has protected against PM-induced lung damage by strong inhibition of oxidative stress and inflammation than single compound treatment. The results showed that PM10 exposure of epithelial cells increased ROS generation and pro-inflammatory cytokines. While, the treatment of SF, CU or combined SF/CU significantly increased the expression of Nrf2-downstream genes such as HO-1, NQO1-1, CAT and TXNRD1 by triggering the activate of Nrf2 transcription in the nucleus and decreased intracellular ROS generation. In addition, these compound strikingly inhibited the production of pro-inflammatory cytokines by downregulation the PM-induced inflammatory mediators, such as IL-6, IL-8, CXCL1 and MCP-1. The combined SF/CU showed the highest effectiveness in PM-induced epithelial injury. We confirmed these compound decreased the NF-κB signaling activation in PM-exposed epithelial cells. These results suggest that the combined SF/CU inhibited PM-induced oxidative stress and inflammation by increasing of antioxidant genes through Nrf2 transcriptional activity and by decreasing of pro-inflammatory cytokines through the mediation of NF-κB signaling. Our findings may provide experimental evidence and explanation for aggravated respiratory diseases by PM.