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> 한국식품영양학회 > 한국식품영양학회지 > 30권 6호

Flavonoid in Clover Honey Exerts a Hypnotic Effect via Positive Allosteric Modulation of the GABAA-BZD Receptor in Mice

Flavonoid in Clover Honey Exerts a Hypnotic Effect via Positive Allosteric Modulation of the GABAA-BZD Receptor in Mice

( Kyoung-sik Han ) , ( Hyejin Yang ) , ( Minseok Yoon )

- 발행기관 : 한국식품영양학회

- 발행년도 : 2017

- 간행물 : 한국식품영양학회지, 30권 6호

- 페이지 : pp.1364-1369 ( 총 6 페이지 )


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4,500
논문제목
초록(외국어)
There is a growing demand for natural sleep aids due to various side effects of long-term administration of pharmacological treatments for insomnia. Honey has been reported to exhibit numerous potential health benefits, and it is hypothesized that honey may favorably affect insomnia treatment. Therefore, this study was performed to investigate the possible hypnotic effect of clover honey (CH) and to determine its in vivo mechanism. The total flavonoid content (TFC) of CH and fractions extracted with ethylacetate (EtOAc) and H2O was measured. The pentobarbital-induced sleep test using GABAA-benzodiazepine (BZD) agonists and antagonists was conducted to evaluate the potential mechanism of action behind the sedative-hypnotic activity of CH in mice. The results showed that administration of 500 and 1,000 mg/kg of CH significantly (p<0.01) reduced the sleep latency to a level similar to that of diazepam (DZP, 2 mg/kg), and 1,000 mg/kg of CH significantly (p<0.01) prolonged the sleep duration, which was comparable to that of DZP (2 mg/kg). Administration of the EtOAc fraction with a higher TFC significantly reduced the sleep latency at 50 to 200 mg/kg and prolonged the sleep duration at 100 to 200 mg/kg, which were comparable to those after administration of DZP (2 mg/kg). However, co-administration of CH and EtOAc with flumazenil, a specific GABAA-BZD receptor antagonist, blocked the hypnotic effect. Our findings suggest that the hypnotic activity of CH may be attributed to allosteric modulation of GABAA-BZD receptors. The TFC of CH is expected to be a key factor that contributes to its hypnotic effect.

논문정보
  • - 주제 : 자연과학분야 > 가정
  • - 발행기관 : 한국식품영양학회
  • - 간행물 : 한국식품영양학회지, 30권 6호
  • - 발행년도 : 2017
  • - 페이지 : pp.1364-1369 ( 총 6 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2018-500-003868680
저널정보
  • - 주제 : 자연과학분야 > 가정
  • - 성격 : 학술지
  • - 간기 : 격월
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 1225-4339
  • - 수록범위 : 1988–2017
  • - 수록 논문수 : 1743