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> 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) > Oral Biology Research (OBR) > 41권 4호

Anti-tumor effect of licochalcone-E is mediated by caspase-dependent apoptosis through extrinsic and intrinsic apoptotic signaling pathways in KB cancer cells

Anti-tumor effect of licochalcone-E is mediated by caspase-dependent apoptosis through extrinsic and intrinsic apoptotic signaling pathways in KB cancer cells

( In-a Cho ) , ( Kyeong-rok Kang ) , ( Su-gwan Kim ) , ( Do Kyung Kim ) , ( Chun Sung Kim ) , ( Sook-young Lee ) , ( Seung Sik Cho ) , ( Goo Yoon ) , ( Byung Soo Park ) , ( Jae-sung Kim )

- 발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소)

- 발행년도 : 2017

- 간행물 : Oral Biology Research (OBR), 41권 4호

- 페이지 : pp.191-200 ( 총 10 페이지 )


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논문제목
초록(외국어)
This study investigates the anti-cancer effects of licochalcone-E (Lico-E), a phenolic chalconoid derived from the genus Glycyrrhiza, in the human KB squamous cancer cell. Concentration-dependent cytotoxicity in KB cells increased following 24 hours of treatment with 12.5, 25, or 50 μg/ml Lico-E, with an estimated IC50 value of approximately 25 μg/ml. Chromatin condensation, a typical apoptotic phenomenon, was observed in KB cells treated with Lico-E. Consistent with this finding, Lico-E increased caspase-3 activity in KB cells. FasL, a death ligand associated with extrinsic apoptotic signaling pathways, was significantly up-regulated by Lico-E treatment. Subsequently, the pro-apoptotic factor caspase-8, a part of the extrinsic apoptotic signaling pathway, was activated in a concentrationdependent manner by Lico-E treatments. Expression of anti-apoptotic factors such as Bcl-2 and Bcl-xL, components of the mitochondriadependent apoptotic signaling pathway, significantly decreased following Lico-E treatment. Conversely, expression of pro-apoptotic factors such as Bax, Bad, Apaf-1, and caspase-9 increased with Lico-E concentrations. Finally, Lico-E activated caspase-3 and Poly (ADP-ribose) polymerase (PARP) to induce cell death. Z-VAD-fmk significantly inhibited cell death through suppression of caspase-3 expression in KB cells treated with Lico-E. Taken together, Lico-E induces KB cell death through death receptor and mitochondriadependent apoptotic signaling pathways.

논문정보
  • - 주제 : 의약학분야 > 기초치의학
  • - 발행기관 : 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소)
  • - 간행물 : Oral Biology Research (OBR), 41권 4호
  • - 발행년도 : 2017
  • - 페이지 : pp.191-200 ( 총 10 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2018-500-004080893
저널정보
  • - 주제 : 의약학분야 > 기초치의학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 2508-2558
  • - 수록범위 : 1978–2021
  • - 수록 논문수 : 1447