Background: Pulsed dye laser (PDL) is considered as treatment of choice for cutaneous capillary malformation. The regeneration or revascularization of blood vessels after PDL treatment is one of the causes of treatment failures. Recently, topical administration of rapamycin (RPM) was introduced as a possible adjunctive therapeutic option to minimize post-laser revascularization in facial capillary malformations. Objectives: We evaluated the effect of combined use of 1% topical RPM with PDL compared to PDL alone in cutaneous capillary malformation of trunk or extremities and tried to identify the effective length of RPM application. Methods: The study design was a prospective side-by-side comparison of 6 patients. Three adjacent areas of cutaneous capillary malformation which had never been treated before were selected in each patient and underwent the following regimens: (A) PDL + vehicle for 8 weeks post-PDL; (B) PDL + topical RPM for 1 week post-PDL; and (C) PDL + topical RPM for 8 weeks post-PDL. Each patient was treated by PDL for two sessions with 8 weeks interval. Topical RPM was applied to the area once daily. Results: Only one of 6 patients showed clinical improvement with combined RPM treatment. Overall, there was no statistically significant difference in erythema and blanching rate among PDL alone and combined topical RPM regimens. Conclusion: In conclusion, topical RPM does not seem to be effective as a treatment modality for non-facial port wine stains.