Lymphangioma circumscriptum (LC) is an uncommon lymphatic malformation characterized by grapelike groups of thin-walled translucent lymph-filled vesicles, often compared to frog spawn. The treatment of LC is challenging and complete surgical excision has the lowest recurrence rate but it is sometimes unavailable because of size of the lesion or cosmetic concern of postsurgical scar on the exposed area. Less invasive therapeutic options including laser or sclerotherapy can be tried but the recurrence tends to be common. A 23-year-old woman presented with papules resembling frog spawn on her left neck. The lesions appeared when she was 4 years old and she had treatment with CO2 laser and vascular laser ten more times at local clinic but they had not been improved enough. Skin biopsy was done from papules on her neck and histopathologic finding was consistent with LC. Surgical excision was unavailable because of the cosmetic concern of postsurgical scar. We instructed the patient to apply topical rapamycin cream twice a day. After 4 months of treatment, the lesions significantly improved in size and color compared to the initial presentation. She also had no side effects on the treated site. To the best of our knowledge, there is only one reported proceeding of topical rapamycin used to manage LC. We report this extremely rare experience of treatment and suggest topical rapamycin can be a good therapeutic option for the management of LC.