Epinephrine is the first-line treatment for anaphylaxis, a life-threatening condition. In cases treated with epinephrine, epinephrineinduced acute myocardial infarction is a rare event, with coronary stent thrombosis being rarer than coronary spasm. case presentation Here, we report the case of a 50-year-old man who developed acute myocardial infarction due to acute coronary stent thrombosis after administration of intravenous epinephrine for anaphylaxis following a bee sting. Thus, we conclude that the acute myocardial infarction was due to stent thrombosis that was caused by exogenous epinephrine administration for anaphylaxis.