Colorectal cancer is common and the liver and lung are frequent metastatic sites. But single metastasis from colorectal cancer to the central airway is extremely rare. In a fatal central airway obstruction, generally, the rigid bronchoscopic interventions or surgical procedures under general anesthesia were the preferred management. However in patients who are not candidates for surgical resection, bronchoscope-guided multidisciplinary approaches offered a safe and effective alternative in the palliative management of respiratory symptoms related with airway obstruction. Of these, argon plasma coagulation (APC) is a valuable tool in treating superficial bleeding and debulking granulation tissue and tumors. In addition cryotherapy relies on repeated freeze/thaw cycles for tissue destruction, and spares cartilaginous structures due to their poor vascularity. Herein, we report an interesting case of the successful debukling management with combined APC and cryotherapy guided by flexible bronchoscopy under the simple sedation in a patient with impending total airway obstruction from colorectal cancer. Colorectal cancer is common and the liver and lung are frequent metastatic sites. But single metastasis from colorectal cancer to the central airway is extremely rare. In a fatal central airway obstruction, generally, the rigid bronchoscopic interventions or surgical procedures under general anesthesia were the preferred management. However in patients who are not candidates for surgical resection, bronchoscope-guided multidisciplinary approaches offered a safe and effective alternative in the palliative management of respiratory symptoms related with airway obstruction. Of these, argon plasma coagulation (APC) is a valuable tool in treating superficial bleeding and debulking granulation tissue and tumors. In addition cryotherapy relies on repeated freeze/thaw cycles for tissue destruction, and spares cartilaginous structures due to their poor vascularity. Herein, we report an interesting case of the successful debukling management with combined APC and cryotherapy guided by flexible bronchoscopy under the simple sedation in a patient with impending total airway obstruction from colorectal cancer.