Catecholamine-induced cardiomyopathy rarely occurs after local epinephrine application. Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is believed to be secondary to a catecholamine surge that is brought on by intense psychological or physical stress. Inverted TC caused by iatrogenic excessive epinephrine administration has recently been reported, thus supporting the role of catecholamine in the pathophysiology of TC. There is no report of inverted TC with ventricular fibrillation after a usual dose of intrabronchial epinephrine administration during bronchoscopy. We present a case of intrabronchial epinephrine-induced inverted TC with ventricular fibrillation in a 31-year-old man with no previous history of cardiac disease.