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> 한국생약학회 > Natural Product Sciences > 15권 2호

Anti-inflammatory Effect of MeOH Extracts of the Stem of Polygonum multiflorum in LPS-stimulated Mouse Peritoneal Macrophages

Anti-inflammatory Effect of MeOH Extracts of the Stem of Polygonum multiflorum in LPS-stimulated Mouse Peritoneal Macrophages

( Dong Seok Cha ) , ( Hoon Jeon )

- 발행기관 : 한국생약학회

- 발행년도 : 2009

- 간행물 : Natural Product Sciences, 15권 2호

- 페이지 : pp.83-89 ( 총 7 페이지 )


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논문제목
초록(외국어)
Polygoni multiflori Ramulus (PM), the stem of Polygonum multiflorum Thunb. has been widely used as a traditional medicine for the treatment of lots of diseases. In macrophages, nitric oxide is released as an inflammatory mediator and has been proposed to be an important modulator of many pathophysiological conditions in inflammation. In the present study, it was investigated that the inhibitory effects on NO and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and the mechanism of down-regulation of immune response by 85% methanol extracts of PM in mouse (C57BL/6) peritoneal macrophages. Extracts of PM (0.1, 1 mg/ml) suppressed NO production and showed inhibition of pro-inflammatory cytokines like TNF-α, IL-6 and it attenuated iNOS and COX-2 expression via down-regulation of NF-кB activation. The present results indicate that the 85% methanol extracts of PM has an inhibitory effect on the production of NO through down-regulation of iNOS expression in LPS stimulated mouse peritoneal macrophages and therefore may be beneficial in diseases which related to macrophage-mediated inflammatory disorders.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 15권 2호
  • - 발행년도 : 2009
  • - 페이지 : pp.83-89 ( 총 7 페이지 )
  • - ECN : ECN-0102-2012-510-000348783
  • - UCI : I410-ECN-0102-2012-510-000348783
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2018
  • - 수록 논문수 : 1049