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> 대한본초학회 > 대한본초학회지(본초분과학회지) > 31권 6호

포부자추출물의 갑상선기능저하증 흰쥐모델에서의 한열조절작용에 의한 개선효능 연구

Effects study of Aconiti Lateralis Radix Preparata extract on the regulation of heat and cold in PTU-induced hypothyroidism rats

황민섭 ( Min Sub Hwang ) , 황지혜 ( Ji Hye Hwang ) , 강석용 ( Seok Yong Kang ) , 강안나 ( An Na Kang ) , 노효선 ( Hyo Sun Roh ) , 박용기 ( Yong-ki Park )

- 발행기관 : 대한본초학회

- 발행년도 : 2016

- 간행물 : 대한본초학회지(본초분과학회지), 31권 6호

- 페이지 : pp.63-71 ( 총 9 페이지 )


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논문제목
초록(외국어)
Objective : To suggest a scientific evidence of Aconitum carmichaeli Debx. (Aconiti Lateralis Radix Preparata: ALRP) as one of cooling and heating medicines on the regulation of body temperature, we investigated the effects of ALRP water extract on hypothyroidism. Methods : Hypothyroidism was induced by intradermal injection with PTU for 4 weeks in SD rats. ALRP extract or L-thyroxine as a control drug was orally administrated for 2 weeks with PTU injection in rats. The physiological and serological parameters were measured in rats. The histological change of thyroid tissues was observed by H&E staining, and also the expression of thermo-regulating proteins was determined by Western blot in dorsal root ganglia and brain tissues of rats. Results : The administration of ALRP extract in PTU-induced hypothyroidism rats was significantly increased body temperature, but did not changes on body weight, food and water intake. ALRP extract did not effect on the levels of TSH and T4 in the hypothyroidism rats. ALRP extract significantly decreased the levels of GPT, glucose, HDL-cholesterol, LDL-cholesterol, and total cholesterol in the hypothyroidism rats. In histological observation, the enlarged epithelium and atrophic follicles with higher concentration of follicular cells on hypothyroidism were improved by ALRP extract. In addition, ALRP extract increased the expression of TRPV1 and TRPM8 ion channel proteins in hypothyroidism rats. Conclusion : These results indicate that ALRP extract can improve PTU-induced hypothyroidism through regulation of body temperature and lipid accumulation. The action mechanism of ALRP extract is related with body temperature control by thermoregulation with TRP ion channels.

논문정보
  • - 주제 : 의약학분야 > 기초한의학
  • - 발행기관 : 대한본초학회
  • - 간행물 : 대한본초학회지(본초분과학회지), 31권 6호
  • - 발행년도 : 2016
  • - 페이지 : pp.63-71 ( 총 9 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2018-500-000285763
저널정보
  • - 주제 : 의약학분야 > 기초한의학
  • - 성격 : 학술지
  • - 간기 : 격월
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : -
  • - ISSN : 1229-1765
  • - 수록범위 : 1986–2020
  • - 수록 논문수 : 1599