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> 한국응용약물학회 > Biomolecules & Therapeutics(구 응용약물학회지) > 22권 1호

Original Article : Beneficial Antioxidative and Antiperoxidative Effect of Cinnamaldehyde Protect Streptozotocin-Induced Pancreatic β-Cells Damage in Wistar Rats

Original Article : Beneficial Antioxidative and Antiperoxidative Effect of Cinnamaldehyde Protect Streptozotocin-Induced Pancreatic β-Cells Damage in Wistar Rats

( P Subash Babu ) , ( Ali A Alshatwi ) , ( Ignacimuthu )

- 발행기관 : 한국응용약물학회

- 발행년도 : 2014

- 간행물 : Biomolecules & Therapeutics(구 응용약물학회지), 22권 1호

- 페이지 : pp.47-54 ( 총 8 페이지 )


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무료
논문제목
초록(외국어)
The present study was aimed to evaluate the antioxidant defense system of cinnamaldehyde in normal, diabetic rats and its possible protection of pancreatic β-cells against its gradual loss under diabetic conditions. In vitro free radical scavenging effect of cinnamaldehyde was determined using DPPH (1,1-diphenyl-2-dipicrylhydrazyl), superoxide radical, and nitric oxide radical. Streptozotocin (STZ) diabetic rats were orally administered with cinnamaldehyde at concentrations of 5, 10 and 20 mg/kg body weight for 45 days. At the end of the experiment, the levels of plasma lipid peroxides and antioxidants such as vitamin C, vitamin E, ceruloplasmin, catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase were determined. A significant increase in the levels of plasma glucose, vitamin E, ceruloplasmin, and lipid peroxides and significant decrease in the levels of plasma insulin and reduced glutathione were observed in the diabetic rats. Also the activities of pancreatic antioxidant enzymes were altered in the STZ-induced diabetic rats. The altered enzyme activities were reverted to near-normal levels after treatment with cinnamaldehyde and glibenclamide. Histopathological studies also revealed a protective effect of cinnamaldehyde on pancreatic β-cells. Cinnamaldehyde enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic conditions and thus protects pancreatic β-cells against their loss and exhibits antidiabetic properties.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국응용약물학회
  • - 간행물 : Biomolecules & Therapeutics(구 응용약물학회지), 22권 1호
  • - 발행년도 : 2014
  • - 페이지 : pp.47-54 ( 총 8 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2014-500-001941842
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 격월
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : SCI / SCOPUS
  • - ISSN : 1976-9148
  • - 수록범위 : 1993–2021
  • - 수록 논문수 : 1706