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> 한국생약학회 > Natural Product Sciences > 19권 4호

Effects of Gypenosides on Acute Stress in Mice

Effects of Gypenosides on Acute Stress in Mice

( Ting Ting Zhao ) , ( Keon Sung Shin ) , ( Hyun Sook Choi ) , ( Myung Koo Lee )

- 발행기관 : 한국생약학회

- 발행년도 : 2013

- 간행물 : Natural Product Sciences, 19권 4호

- 페이지 : pp.337-341 ( 총 5 페이지 )


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논문제목
초록(외국어)
The effects of gypenosides (GPS) on electric footshock (EF)-induced acute stress in mice were investigated. Mice were treated orally with GPS (30 - 400 mg/kg) once a day for 5 days. After 2 days of GPS treatment, mice were exposed to EF stimuli (intensity, 2 mA; interval, 10 s; duration, 3 min) for acute stress for 3 days. Spontaneous locomotor activity was increased by acute EF stress, which was decreased by treatment with GPS (100 and 400 mg/kg). In addition, the increased levels of dopamine and serotonin by acute EF stress in the brain were reduced by treatment with GPS (100 and 400 mg/kg). The serum levels of corticosterone increased by acute EF stress were also reduced by GPS (100 and 400 mg/kg). These results suggest that GPS shows the ameliorating effects on acute EF stress by modulating the activity of dopaminergic and serotonergic neurons, and the serum levels of corticosterone. Clinical trials of GPS need to be conducted further so as to develop promising anti-stress agents.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 19권 4호
  • - 발행년도 : 2013
  • - 페이지 : pp.337-341 ( 총 5 페이지 )
  • - ECN : ECN-0102-2014-500-001880944
  • - UCI : I410-ECN-0102-2014-500-001880944
저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2018
  • - 수록 논문수 : 1062