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> 한국응용생명화학회(구 한국농화학회) > Journal of Applied Biological Chemistry > 56권 1호

Short Communication: Bioactive Materials : Anticancer and Antimicrobial Activities of 13(E)-labd-13-ene-8α,15-diol from Brachyglottis monroi

Short Communication: Bioactive Materials : Anticancer and Antimicrobial Activities of 13(E)-labd-13-ene-8α,15-diol from Brachyglottis monroi

( Jong Im Kim ) , ( Hwa Jung Choi ) , ( Jae Sook Lee )

- 발행기관 : 한국응용생명화학회(구 한국농화학회)

- 발행년도 : 2013

- 간행물 : Journal of Applied Biological Chemistry, 56권 1호

- 페이지 : pp.49-51 ( 총 3 페이지 )


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초록(외국어)
In a previous study, we reported that 13(E)-labd-13- ene-8α, 15-diol (13E) possesses antiviral and anticancer activities. In this study, the anticancer and antimicrobial activities of 13(E) were evaluated against 4 cancer cell lines and 6 bacteria. 13(E) showed inhibitory effect on a variety of cancer cell lines. The IC50 values was 8.3-21.3 μg/mL. 13(E) was the most effective growth inhibitor of murine leukaemia cell lines P388, producing approximately 8.3 μg/mL of IC50 in the cytopathic effect (CPE) method. 13(E) also inhibited the growth of the gram-positive bacteria (Staphyl℃℃cus aureus, Bacillus cereus and Listeria mon℃ytogenes) and gram-negative bacteria (Vibrio parahaemolyticus, Escherichia coli and Salmonella enteritidis) with a range of minimum inhibitory concentration (MIC) values from 0.092 to 0.598 mg/mL and gram-negative bacteria were more sensitive to the compound (MIC, 0.092 mg/mL).

논문정보
  • - 주제 : 농학분야 > 농화학
  • - 발행기관 : 한국응용생명화학회(구 한국농화학회)
  • - 간행물 : Journal of Applied Biological Chemistry, 56권 1호
  • - 발행년도 : 2013
  • - 페이지 : pp.49-51 ( 총 3 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2014-500-001987826
저널정보
  • - 주제 : 농학분야 > 농화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1976-0442
  • - 수록범위 : 1999–2020
  • - 수록 논문수 : 1387