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> 한국조직공학·재생의학회 > 조직공학과 재생의학 > 3권 3호

Genetic Association of the ACE Gene Polymorphisms with Essential Hypertension in Korean Females

Genetic Association of the ACE Gene Polymorphisms with Essential Hypertension in Korean Females

( Hyun Joon Shin ) , ( Dong Hoon Choi ) , ( Sung Joo Kim ) , ( Yang Soo Jang ) , ( Sung Ha Park ) , ( Ji Hyung Chung ) , ( Dong Jik Shin ) , ( Chan Mi Park ) , ( Young Guk Ko ) , ( Ki Chul Hwang ) , ( Ji Hye Han ) , ( Yoon Sun Bae )

- 발행기관 : 한국조직공학·재생의학회

- 발행년도 : 2006

- 간행물 : 조직공학과 재생의학, 3권 3호

- 페이지 : pp.319-326 ( 총 8 페이지 )


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논문제목
초록(외국어)
The renin-angiotensin system(RAS) genes have been extensively studied as etiologic essential hypertension( EH) candidate genes in human populations worldwide. The angiotensin I-converting enzyme(ACE) plays a key role in the RAS for the regulation of blood pressure. Recent studies on the association of ACE gene polymorphisms with EH and the related cardiovascular diseases presented conflicting results. Therefore, we investigated the association of three polymorphisms(I/D, G14480C and A22982G) in the ACE gene with EH in Koreans. We studied a sample population of 699 Koreans, comprising of 471 controls and 228 cases with EH, which were recruited from Cardiovascular Genome Center in Korea. The ACE gene polymorphisms were determined by polymerase chain reaction and SNP-IT assay. The allele frequency of G14480C polymorphism showed significant difference between normotensives and hypertensives in female group(P=0.0353). After adjustment for age and BMI, logistic regression analysis indicated that the odds ratio(OR) of the ACE I carriers(II+ID) for a risk of EH over the DD genotype was 1.698(95% CI, 1.006-2.864, P=0.0458), and OR for the comparison of 14480 GG subjects versus GC and CC subjects combined was for EH 1.787(95% CI, 1.076-2.967, P=0.0236) in females. In haplotype analysis, major three haplotypes(ICA, IGG, and DGG) were significantly associated with EH in study populations. We conclude that ACE polymorphisms appeared to have apparent association with EH in Koreans, who have a more homogeneous genetic structure than any other ethnic groups.

논문정보
  • - 주제 : 의약학분야 > 의공학
  • - 발행기관 : 한국조직공학·재생의학회
  • - 간행물 : 조직공학과 재생의학, 3권 3호
  • - 발행년도 : 2006
  • - 페이지 : pp.319-326 ( 총 8 페이지 )
  • - UCI(KEPA) : I410-ECN-0102-2013-510-002326721
저널정보
  • - 주제 : 의약학분야 > 의공학
  • - 성격 : 학술지
  • - 간기 : 반년간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : SCI / SCOPUS
  • - ISSN : 1738-2696
  • - 수록범위 : 2004–2015
  • - 수록 논문수 : 718