글로버메뉴 바로가기 본문 바로가기 하단메뉴 바로가기

논문검색은 역시 페이퍼서치

> 한국생약학회 > Natural Product Sciences > 18권 1호

Actinidia arguta Protects Cultured Cerebral Cortical Neurons against Glutamate-Induced Neurotoxicity via Inhibition of [Ca2+]i Increase and ROS Generation

Actinidia arguta Protects Cultured Cerebral Cortical Neurons against Glutamate-Induced Neurotoxicity via Inhibition of [Ca2+]i Increase and ROS Generation

( Jae Hee Cho ) , ( Hong Kyu Lee ) , ( Yeon Hee Seong )

- 발행기관 : 한국생약학회

- 발행년도 : 2012

- 간행물 : Natural Product Sciences, 18권 1호

- 페이지 : pp.26-31 ( 총 6 페이지 )


학술발표대회집, 워크숍 자료집 중 1,2 페이지 논문은 ‘요약’만 제공되는 경우가 있으니,

구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

4,000
논문제목
초록(외국어)
Actinidia arguta (Actinidiaceae) has been reported to have several pharmacological effects such as anti-inflammatory, anti-allergic, and anti-oxidant activities. The present study investigated the protective activity of an ethanol extract from the leaf and stem of A. arguta against glutamate-induced neurotoxicity using cultured rat cortical neurons. Exposure of cultured cortical neurons to 500 uM glutamate for 12 h triggered neuronal cell death. A. arguta inhibited glutamate-induced neuronal death and apoptosis, which were measured by a 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl-tetrazolium bromide (MTT) assay and Hoechst 33342 staining, respectively. The increase of pro-apoptotic proteins, Bax and c-caspase-3, in glutamate-treated neurons was significantly inhibited by treatment with A. arguta. A. arguta also inhibited 500 uM glutamate-induced elevation of intracellular calcium concentration ([Ca2+]i) and reactive oxygen species (ROS) generation, which were measured by fluorescent dyes, Fluo-4 AM and H2DCF-DA, respectively. These results suggest that A. arguta may prevent glutamate-induced apoptotic neuronal death by inhibiting [Ca2+]i elevation and ROS generation and, therefore, may have a therapeutic role for the prevention of neurodegeneration in cerebral ischemic diseases.

논문정보
  • - 주제 : 의약학분야 > 약화학
  • - 발행기관 : 한국생약학회
  • - 간행물 : Natural Product Sciences, 18권 1호
  • - 발행년도 : 2012
  • - 페이지 : pp.26-31 ( 총 6 페이지 )
  • - ECN :
  • - UCI : I410-ECN-0102-2012-510-003212499

저작권 안내

한국학술정보(주)의 모든 학술자료는 각 학회 및 기관과 저작권 계약을 통해 제공하고 있습니다.
이에 본 학술자료를 상업적 이용, 무단 배포 등 불법적으로 이용할 시에는 저작권법 및 관계법령에 따른 책임을 질 수 있습니다.

저널정보
  • - 주제 : 의약학분야 > 약화학
  • - 성격 : 학술지
  • - 간기 : 계간
  • - 국내 등재 : KCI 등재
  • - 해외 등재 : - / SCOPUS
  • - ISSN : 1226-3907
  • - 수록범위 : 1995–2017
  • - 수록 논문수 : 989