Background: Individuals with chronic kidney disease experience higher mortality and adverse cardiovascular event rates. This study will describe the association between serum urea and creatinine level with different groups of Framingham Risk Score. Methods: Respondents who met the inclusion criteria and gave consent to participate will be recruited. This cross sectional study was conducted in Raub, Malaysia between July 2010 and June 2011. Blood pressure was measured twice and the average was recorded. Venous blood samples were taken for Fasting Serum Lipid, Fasting Blood Glucose and for the determination of urea and creatinine concentration. Results: There were 480 respondents recruited in this study with 42.5% of respondents were males (mean age±SD, 59±10.2 years). Urea concentration was found significantly higher in males (4.8±1.84 mmol/L) compared to females (4.2±1.77 mmol/L) (p<0.001). Creatinine concentration was found signifi cantly higher in males (88±31.45 mmol/L) compared to females (63.6±22.38 mmol/L) (p<0.001). Bivariate correlations found that age was significantly correlated with urea (r= 0.255, p<0.001) and creatinine (r=0.233, p<0.001) of the respondents. One way between groups analysis revealed that mean concentration of urea was signifi cantly highest in the high risk group, followed by moderate and low risk group of the Framingham Risk Score (F(2,438)=13.622, p<0.001). Creatinine concentration also was found signifi cantly highest in the high risk group followed by moderate and low risk group (F(2,438)=38.348, p<0.001). Conclusions: Serum urea and creatinine level were signifi cantly highest among the high risk for CVD group. Increasing public health awareness and aggressive lifestyle modifi cation programmes are essential in combating this serious health problem.