Objective: This study investigated the effects of Weissella confusa, WIKIM51 on the programmed obesity induced by maternal diet. Methods: Pregnant rats were divided into four groups: 1) AdLib/AdLib (control; given a normal diet during the experimental period), 2) FR/AdLib (given a food restriction diet during pregnancy and a normal diet during lactation), 3) HF/AdLib (given a high fat diet during pregnancy and a normal diet during lactation), 4) HF/HF (given a high fat diet during the experimental period). In each group, 10-week-old offspring were randomly divided into 2 groups and fed WIKIM51 for 6 weeks. We measured the body weight and dietary intake of the offspring, and analysed lipid profiles. The liver and lipid droplets were observed by histopathological analysis. The mRNA and protein levels of hepatic lipid metabolism-related genes were measured by real-time PCR and a western blot. Statistical analysis were performed using SPSS ver. 21. Results: Birth weight significantly decreased among FR offspring compared to the other 3 groups. At 10 weeks of age, the weight of the FR offspring significantly decreased compared to the weight of the control group, while the weight of the obese offspring significantly increased. After taking WIKIM51, body weight at 16-weeks significantly decreased in the FR and HF group compared to those that did not take WIKIM51 (P<0.05). In addition, weight gain significantly decreased in all groups compared to those that did not take WIKIM51 (P<0.05). Blood glucose levels of FR offspring consuming WIKIM51 also decreased, as did blood triglyceride levels of obese offspring consuming WIKIM51. Furthermore, hepatic cell size decreased in all offspring consuming WIKIM51 compared to those that did not take WIKIM51. The expression and protein levels of hepatic lipid metabolism related genes were altered in all offspring consuming WIKIM51. Conclusion: Our findings suggest that WIKIM51 intake will help to recover the adverse health outcomes of offspring induced by maternal diet.