Objective: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been suggested as an alternative option for treating peritoneal carcinomatosis (PC). However, even with its clinical advantages, the current PIPAC system still suffers from limitations regarding area of drug distribution and penetration depth. Thus, we evaluated another PIPAC system using a novel prototype, and compared its performance to results of previous studies related to the current MIP. However, the comparison was only done indirectly as this system is currently not available for purchase in the market. Methods: The developed prototype includes a syringe pump, nozzle, and controllers (Figure 1). Drug distribution was evaluated using a methylene blue solution while the penetration depth was assessed by conducting an ex-vivo experiment with porcine tissues in a 3.5l plastic box. Doxorubicin was sprayed using the novel prototype, and its penetration depth was investigated by confocal laser scanning microscopy. The experiment was repeated with varying nozzle levels beginning from the bottom. The novel prototype sprayed approximately 30 m drug droplets at a flow rate of 30 ml/min with 7 bars of pressure. Results: The average diameter of sprayed region with concentrated dye was 18.5±1.2 cm, which was comparable to that of the current MIP (about 10 cm; Figure 1). The depth of concentrated diffusion (DCD) did not differ among varying nozzle levels, whereas the depth of maximal diffusion (DMD) decreased with increasing distance between the prototype and the bottom (mean values, 515.3 um at 2 cm; 437.6 um at 4 cm; 363.2 um at 8 cm), which was comparable to those of the current MIP (about 350-500 um; Figure 2). Conclusion: We developed a novel prototype that can generate small droplets for drug aerosolization and can produce an equally widely sprayed area and deep penetration compared to the current MIP but at a lower pressure.