Aims: Sarcopenia and osteoporosis are frequent complications in patients with liver cirrhosis. The aim of this study was to investigate the prognostic impact of skeletal muscle mass and bone mineral density in these patients. Methods: We included retrospectively cirrhotic patients who underwent both computed tomography scans (CT) and hepatic venous pressure gradient (HVPG) measurement between December 2009 and March 2015. Single transverse CT image at the level of the third lumbar vertebra (L3) were used to evaluate skeletal muscle area, visceral and subcutaneous fat. The mean CT attenuation of the trabecular bone of the vertebral body in L4 (L4_HU) was measured. Results: A total of 160 cirrhotic patients were enrolled. The mean age of the patients was 52.9 years with men predominating (n=116, 72.5%) and most of the cause was alcohol (62.5%). Forty-nine patients (30.6%) died during a median follow-up period of 39.6 months (range, 3.6-87.6). In multivariate analyses, HVPG (hazard ratio [HR] 1.069, 95% confidence interval [CI] 1.011-1.130; P=0.018), Model for End-Stage Liver Disease (MELD) scores (HR 1.081, 95% CI 1.014-1.153; P=0.018), presence of sarcopenia (HR 1.859, 95% CI 1.004- 3.443; P=0.049) and L4_HU (HR 1.839 for L4_HU < 145 HU, 95% CI 1.013-3.338; P=0.045) were independently associated with long term mortality. In patients with low MELD score (<10), HVPG (HR 1.161, 95% CI 1.040-1.296; P=0.008) and L4_HU (HR 4.173 for L4_HU < 145 HU, 95% CI 1.501-11.598; P=0.006) were independent predictors of mortality, but and presence of sarcopenia was not significant. Conclusions: Muscle mass and bone mineral density, together with the known MELD and HVPG, were associated with longterm prognosis in cirrhotic patients. Especially, in low MELD score, low bone mineral density was independently associated with long-term mortality. It is necessary to identify prognostic roles of liver-muscle-bone according to the degree of cirrhosis.