Purpose Phosphoinositide 3- kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathways is considered as the singling pathway which activates the diverse cellular function viz., survival, cell expansion, vesicular transport and proliferation and found frequently dysregulated pathway in lung cancer. Consequently, flavonoids-based inhibitors play a key kinase role in the pathway including mTOR, PI3K and AKT, have been extensively scrutinized in targeting the oncology in recent years. The common pathway to PI3K-Akt-mTOR used to target during the lung cancer therapy. Therefore, the current study was aimed to peruse the resveratrol as dual PI3K/mTOR for lung cancer. Method In the current experimental study mice were randomly divided into different groups. The oxidative stress was evaluated in term of antioxidant parameters, interleukin (IL)-1β,tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 were measured via using the standard enzyme-linked immunosorbent assay kits. The concentration of PI3K, P-PI3K, mTOR,P-mTORAkt and P-Akt were determined via using the Western blot techniques. We also performed the histopathological study to identify the changes during the disease. Result Resveratrol significantly suppressed the oxidative stress via improving the status of endogenous antioxidant parameters such as SOD (43.4%), CAT (48.5%), GSH (52.4%) and MPO (47.6%); proinflammatory cytokines including TNF-α (49.5%), IL-6 (43.4%), IL-1β (53.4%) in a dose dependent manner. Disease control group mice confirmed the change in protein levels of PI3K/Akt/ mTOR pathway in lung as compared to normal control, which were significantly down-regulated by the Resveratrol in a dose dependent manner. In the histological study, we observed that the Resveratrol substantially reduced the benzopyrene induced neutrophils in lung tissue. Conclusion It can be concluded that Resveratrol has shown promising anticancer effect via attenuation of PI3K/Akt/mTOR against lung cancer and signifies the potential therapeutic relevance for further development.