Background/Aim: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition requiring therapeutic management to be tailored to the clinical characteristics and disease severity of the individual patient. Due to scarcity of studies about racial differences in COPD patients, in this study, we compared clinical characteristics between Asian and other patients of COPD. Method: This was an international, multicenter, prospective study of a cohort of patients with COPD aimed to validate the concept of clinical control in COPD. We compared two subgroups (Asian versus others) by using clinical criteria, questionnaires (COPD Assessment Test -CAT- or Clinical COPD Questionnaire -CCQ-) and recent concept of control. Results: A total of 349 patients were analysed, 110 (32%) patients were Asian and 239 (68%) patients were others. There was a significant difference at sex, smoking status and BMI between Asian and others. Among clinical characteristics, there was a significant difference at median FEV1 (mL), and percentage of patients who have emphysema between two subgroups. Also, number of exacerbation and hospital admission, median CCQ score and recent concept of Impact (Clinical approach by mMRC, rescue medication, time walked/day and sputum color) were the characteristics which show significant disparities between two subgroups. Conclusion: This study showed significant differences in various factors between Asian and other patients of COPD. These results suggest that therapeutic management of COPD should be tailored to the ethnic group of the individual patients