Background: Non-adherence to treatment of tuberculosis (TB) is a major barrier to TB control. Objective:We investigated the effectiveness of Medication Event Monitoring System (MEMS) as a tailored adherence-promoting intervention for improving patients’ adherence to TB treatment in Morocco. Method: The outcome of TB treatment were compared between the patients who received MEMS and the patients who received standard TB care among patients confirmed by sputum acid fast bacilli smear. Standard TB care was based on directly observed treatment (DOT) and self-administration-treatment. Results of participants, recruited between April 2014 and August 2015, were retrospectively analyzed. The patients from 5 health centers who received MEMS (MEMS group) were compared with the patients from 7 health centers who received standard of care (control group) during same period in Morocco, Sale region. Results: One hundred three patients in MEMS group and 161 patients in control group were compared. The mean age (37.2 ± 16.3 VS. 36.1 ± 15.9) and the male-to-female ratio (73:30 VS. 111:50) were not different between two groups. The mean adherence rate in MEMS group was 94.3%. The cure rate and the completion rate in MEMS group were 33.7%, and 64.4%, respectively. Those in control group were 12.4%, and 65.2%, respectively. The default rate were significantly lower in MEMS group than in control group [1% (1/103) VS. 19.3% (31/161), odds ratio=0.04 (0.01-0.31), p < 0.01] Conclusion: MEMS could reduce the default rate of infectious TB patients in Morocco, Sale region.